Gender may play role in presentation, prognosis of thyroid eye disease

Time-from-diagnosis of thyroid eye disease (TED) to Clinical-Activity-Score (CAS) ≥3 was shorter for women than men, according to a study.

In this longitudinal cohort study, 132 patients diagnosed with TED were included. Of 132 patients, 72.21% were women. Active disease, defined as CAS ≥3, was found in 6 men and 20 women during the follow-up period. The mean time from TED diagnosis to CAS ≥3 was 4.50 and 2.35 years for men and women, respectively.

No significant differences in mean total Graves’ Orbitopathy-Quality-of-Life questionnaire (GO-QOL) score between men and women was found. The mean GO-QOL subtotal score of the external appearance of women was significantly lower compared to men in the first and last visit.

Reference
Zloto O, Sagiv O, Priel A, et al. Gender differences in clinical presentation and prognosis of thyroid eye disease. Eur J Ophthalmol. 2020 Nov 6:1120672120964112. doi: 10.1177/1120672120964112. Epub ahead of print. PMID: 33158379.