Study Identifies Improved Carfilzomib Dosing Strategy for Relapsed/Refractory Multiple Myeloma
In the phase 3 ARROW study of carfilzomib (Kyprolis) in adults with relapsed or refractory multiple myeloma, once-weekly dosing was associated with significantly longer progression-free survival (PFS) than twice-weekly dosing (hazard ratio, 0.69; 95% CI, 0.54-0.83); P = .0029). Median PFS was 11.2 months (95% CI, 8.6-13.0 mo) in the once-weekly group (n = 240) versus 7.6 months (95% CI, 5.8-9.2 mo) in the twice-weekly group (n = 238). Once-weekly dosing was also associated with lower rates of grade 3 or worse cardiac failure. The findings led trial-sponsor Amgen to file a supplemental New Drug Application with the FDA in August to include a once-weekly dosing option in the prescribing information for Kyprolis.
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Moreau P, Mateos MV, Berenson JR, et al. Once weekly versus twice weekly carfilzomib dosing in patients with relapsed and refractory multiple myeloma (A.R.R.O.W.): interim analysis results of a randomised, phase 3 study. Lancet Oncol. 2018l;19(7):953-964. doi: 10.1016/S1470-2045(18)30354-1. Erratum in: Lancet Oncol. 2018;19(8):e382.