CRC screening in healthy patients older than 75 with increased risk of complications
In asymptomatic patients >75 years of age undergoing colorectal cancer (CRC) screenings, life expectancy is limited, and colorectal cancer screenings are rare, according to a study. In addition, screening colonoscopies in these patients is associated with an increased risk of complications.
In this cross-sectional study with a nested cohort, 7067 patients >75 years of age who underwent screening colonoscopy in the outpatient setting had life expectancy predicted and colonoscopy findings and adverse events evaluated.
The proportion of colonoscopies performed on patients with a life expectancy of fewer than 10 years was 30% and increased with age, with 100% of patients beyond the age of 85 years. Adverse events requiring hospitalizations were common at 10 days and increased with age, particularly among patients older than 85 years. The detection of advanced neoplasia varied with age, with the highest rate among patients older than 85 years. Invasive adenocarcinoma was found in 0.2% of the total population, and treatment rates varied based on life expectancy.
El Halabi J, Burke CA, Hariri E, et al. Frequency of Use and Outcomes of Colonoscopy in Individuals Older Than 75 Years. JAMA Intern Med. Published online April 03, 2023. doi:10.1001/jamainternmed.2023.0435