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Journal Scan
Neurology

Study Identifies Cortically Driven Process in Lennox-Gastaut Syndrome

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A study assessing brain regions underlying interictal generalized paroxysmal fast activity (GPFA) found reproducible evidence of a cortically driven process within the epileptic network of Lennox-Gastaut syndrome (LGS). The study included 10 children and 15 adults who underwent concurrent scalp EEG-fMRI with and without anesthesia, respectively, during which a total of 1045 GPFA events were identified (cumulative duration, 1433 seconds). Assessment of these events revealed the following:

  • Activation occurred in distributed association cortical areas, thalamus, and brainstem (P <.05, corrected for family-wise error).
  • Activation was similar across individual patients, particularly in the frontoparietal cortex, regardless of the etiology of their epilepsy (ie, structural, genetic, unknown).
  • Dynamic casual modeling indicated GPFA was most likely driven by the prefrontal cortex, with propagation occurring first to the brainstem and then from the brainstem to the thalamus.

Read more here.

Reference

Warren AEL, Harvey AS, Vogrin SJ, et al. The epileptic network of Lennox-Gastaut syndrome: cortically driven and reproducible across age. Neurology. 2019 Jun 21. pii: 10.1212/WNL.0000000000007775. doi: 10.1212/WNL.0000000000007775.

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