Cabaletta Bio Announces Presentation of Preclinical Data Showing Specific CAAR T Activity against Anti-MuSK Expressing B Cells
Cabaletta Bio, Inc, a clinical stage biotechnology company focused on the discovery and development of engineered T cell therapies for patients with B cell-mediated autoimmune diseases, announced a preclinical in vitro study demonstrating specific killing of anti-muscle-specific tyrosine kinase (MuSK) antibody-expressing target cells by Chimeric AutoAntibody Receptor T (CAAR T) cells. The ability to target antibody-expressing cells with a CAAR T cell may provide a new approach to the treatment of MuSK-associated myasthenia gravis (MG). The study has been featured by and will be presented at the American Neurological Association (ANA) 2019 Annual Meeting, October 13 to 15, in St. Louis.
“MuSK myasthenia gravis is a serious antibody-mediated disease with limited therapeutic options. The pathogenic antibodies that cause MuSK MG are well-defined suggesting that this disease is an ideal candidate for our CAAR T approach,” said Aimee Payne, M.D., Ph.D., co-founder and co-chair of the Scientific Advisory Board at Cabaletta Bio and the Albert M. Kligman Associate Professor of Dermatology in the Perelman School of Medicine at the University of Pennsylvania and a member of Penn’s Abramson Cancer Center. “The preclinical data establish the in vitro function of a MuSK CAAR T cell against multiple epitopes on the target B cells.”
Gwendolyn Binder, Ph.D., EVP Science and Technology at Cabaletta Bio, added, “This research from our co-founder and collaborators at the University of Pennsylvania is expected to form the basis of our second cell therapy product candidate, MuSK-CAART. As part of our cooperative mission with our cofounders, we look forward to continuing to advance this pipeline program and potential therapy for patients with MuSK MG.”
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