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Lupus Nephritis

Treatment response at 6 months may predict poor long-term renal outcomes in lupus nephritis

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Patients with lupus nephritis (LN) with poor renal function who had no response 6 months after starting induction therapy may have worse long-term renal outcomes, according to a study.

In this study, 107 patients with active LN with poor renal function receiving induction therapy were included. Poor renal function was defined as an estimated glomerular filtration rate (eGFR) between 15 and 59 mL/min/1.73 m2.

After 6 months, 18.7% of patients achieved complete response (CR), 38.3% achieved partial response (PR), and 43% had no response.

After a median follow-up of 60 months, 40.2% and 14% of patients had reduced renal function and end-stage renal disease, respectively; researchers determined that there was a significantly higher proportion of patients with no response at 6 months amongst these patients.

Baseline eGFR ≤33 mL/min/1.73 m2, fibrous crescent, and no response at 6 months were found to independently predict ESRD.

Reference
Luo H, Zhou Y, Chen G, et al. Response to therapy at 6 months predicts long-term renal outcome in lupus nephritis with poor kidney function. Lupus Sci Med. 2022;9(1):e000773. doi: 10.1136/lupus-2022-000773. PMID: 36581380; PMCID: PMC9806010.

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