Predictors of lupus nephritis outcomes remain stagnant
There are no new biomarkers that identify the renal prognosis of patients with lupus nephritis (LN), instead, classic clinical, renal, and histological markers continue to be used, according to a study in Lupus.
A lack of clear definition of renal outcomes may be complicating risk stratification in patients with LN, according to the authors.
A total of 25 studies (15 retrospective, 9 prospective, and 1 a trial extension study) on all targeted outcomes of LN, including kidney failure, response to treatment, cardiovascular events, and mortality, were included.
Predictive factors of renal response:
-Serum creatinine and glomerular filtration rate C3 levels
-Titer of anti-C1q
-Anti-dsDNA antibodies
Risk factors for the development of chronic kidney disease:
-Class type IV or V
-Tubulointerstitial or vascular lesions
-Chronicity index
Factor associated with persistence of activity:
-Proteinuria
-Anti-dsDNA, anticardiolipin
-Anti C1q antibodies
-Complement values.
The factors associated with cardiovascular events/mortality:
-Age
-Smoking
-Amount of proteinuria
-Histological findings.
Reference
Rodríguez-Almaraz E, Gutiérrez-Solís E, Rabadán E, et al. Something new about prognostic factors for lupus nephritis? A systematic review. Lupus. 2021;doi: 10.1177/09612033211061475. Epub ahead of print. PMID: 34907831.
