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Internal Medicine

Psychiatric comorbidities in liver cirrhosis hospitalizations continue to increase

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Over the last decade, the prevalence of psychiatric comorbidities in liver cirrhosis hospitalizations has increased, with female patients having a higher association than males, according to a study.

Utilizing a national database, researchers identified patients with a primary diagnosis of liver cirrhosis.

From 2009 to 2019, the following psychiatric comorbidities increased:
-Generalized anxiety disorder (0.17% to 0.92%)
-Depression increased (7% to 12%)
-Attention deficit hyperactivity disorder (0.06% to 0.24%)
-Schizophrenia (0.59% to 0.87%)
-Schizoaffective disorder prevalence (0.10% to 0.35%)
-Post-traumatic stress disorder (0.36% to 0.93%)
-Suicidal ideation (0.23% to 0.56%)

Cirrhosis related to alcoholic liver disease and non-alcoholic fatty liver disease was associated with depression more than other causes.

Compared to males, females had a higher association with:
-Generalized anxiety disorder
-Depression
-Bipolar disorder
-Chronic fatigue

Reference
Patel P, Ali H, Inayat F, et al. Racial and gender-based disparities and trends in common psychiatric conditions in liver cirrhosis hospitalizations: A ten-year United States study. World J Hepatol. 2023;15(2):289-302. doi: 10.4254/wjh.v15.i2.289. PMID: 36926245; PMCID: PMC10011900.

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