Pulmonary CT findings offer insights into IgG4-related disease
Pulmonary involvement in IgG4-related disease is common, with bronchovascular changes being the most frequent subtype observed on chest CT scans, according to a study. In the study, CT scans from 28 patients were reviewed. Lung lesions were categorized into 4 subtypes: nodules, ground-glass opacity, interstitial-alveolar, and bronchovascular involvement. Pleural lesions and mediastinal adenopathy were also assessed.
Pulmonary involvement was observed in 61% of patients (17 out of 28). The most common subtype was bronchovascular involvement (100%), followed by interstitial-alveolar involvement (59%), ground-glass opacity (36%), and nodules (29%). Pleural lesions and mediastinal adenopathy were found in 12% and 23% of cases, respectively. Patients without pulmonary involvement had significantly higher serum IgG4 levels compared to those with pulmonary findings (P= 0.022).
Reference
Gallo JR, Froullet C, Varizat A, et al. Clinical and Imaging Pulmonary Manifestations in IgG4-Related Disease. J Clin Rheumatol. 2024;doi: 10.1097/RHU.0000000000002160. Epub ahead of print. PMID: 39823236.