Comparative study highlights diagnostic accuracy of criteria for IgG4-RD
A new study compared the effectiveness of 3 major classification criteria—Okazaki, Umehara, and ACR/EULAR 2019—in diagnosing immunoglobulin G4-related disease (IgG4-RD). Conducted at a single tertiary hospital, the retrospective study evaluated 41 patients with suspected IgG4-RD, using expert clinical judgment as the benchmark.
Of the participants, 30 were confirmed to have IgG4-RD, while 11 were classified as mimickers. The Umehara criteria emerged as the most sensitive (83.33%), followed by the ACR/EULAR 2019 (66.67%) and Okazaki (60.0%) criteria. All 3 criteria demonstrated 100% specificity, with overall diagnostic accuracy ranging from 70% to 88%. The Umehara criteria also achieved the highest area under the curve (AUC) at 0.917, compared to 0.833 for ACR/EULAR 2019 and 0.800 for Okazaki.
Subtype analyses revealed that Umehara and ACR/EULAR 2019 criteria were more effective for diagnosing pancreato-hepato-biliary involvement, while Okazaki and ACR/EULAR 2019 criteria performed better for retroperitoneal fibrosis and aortitis.
Reference
Lopez-Gomez M, Moya-Alvarado P, Park HS, et al. Comparative Analysis of Classification Criteria in IgG4-Related Disease and Evaluating Diagnostic Accuracy from a Retrospective Cohort in Clinical Practice. Diagnostics (Basel). 2024;14(22):2583. doi: 10.3390/diagnostics14222583. PMID: 39594249; PMCID: PMC11593256.
