Postmenopausal women and older men with chronic HypoPT face higher osteoporosis risk

Postmenopausal women and men over 50 with chronic hypoparathyroidism (HypoPT) are at a higher risk of osteoporosis and fragility fractures, according to a study. Current guidelines do not require routine evaluation, but the study suggests that regular assessment could help prevent fractures and improve patient outcomes.

The study evaluated 101 adults with chronic HypoPT, including 18 men and 83 women, of whom 48 were postmenopausal. Although premenopausal women showed no signs of osteoporosis or fragility fractures, 35% of postmenopausal women were diagnosed with osteoporosis based on bone mineral density or prior fragility fractures, with 4% meeting both criteria. In addition, among 9 men over 50, 3 (33.3%) had osteoporosis.

These findings highlight the need for closer skeletal health surveillance in postmenopausal women and older men with chronic HypoPT.

Reference
Khan AA, AbuAlrob H, Ali DS, et al. Skeletal health status among patients with chronic hypoparathyroidism: results from the Canadian National Hypoparathyroidism Registry (CNHR). Osteoporos Int. 2025;doi: 10.1007/s00198-025-07410-7. Epub ahead of print. PMID: 39955688.