Global review underscores the need for collaboration in hypoparathyroidism care

Although hypoparathyroidism management practices in Eastern and Western countries share similarities, such as the use of calcium and vitamin D supplements, there are significant differences, particularly in access to parathyroid hormone (PTH) replacement therapy, which is largely unavailable in Eastern countries, according to a study.

A recent comprehensive review endorsed by the European Calcified Tissue Society highlights the similarities and differences in hypoparathyroidism management between these regions.

The review, based on literature from countries including China, South Korea, Japan, India, the USA, Canada, and Italy, found that postoperative hypoparathyroidism remains the most common form in both regions. Genetic profiles and clinical features were comparable, with calcium and vitamin D supplementation as the cornerstone of treatment globally. However, a significant disparity lies in access to PTH replacement therapy, which is unavailable or unapproved in most Eastern countries.

The authors emphasize the importance of adhering to thyroid nodule management guidelines and taking extra precautions to preserve parathyroid glands during surgery. They advocate for continued collaboration between Eastern and Western experts to refine hypoparathyroidism management strategies.

Reference
Yang YY, Deng YH, Sun LH, Rejnmark L, Wang L, Pietschmann P, Glüer CC, A Khan A, Minisola S, Liu JM. Hypoparathyroidism: Similarities and differences between Western and Eastern countries. Osteoporos Int. 2025;doi: 10.1007/s00198-024-07352-6. Epub ahead of print. PMID: 39777494.