Liposorber D demonstrates efficacy in HoFH pregnancy management

Liposorber D, a whole blood lipoprotein apheresis (LA) technique, appears to be a safe and effective treatment option for managing cholesterol levels in pregnant patients with homozygous familial hypercholesterolemia (HoFH), according to a case report.

The case involved a 31-year-old woman with HoFH who underwent successful pregnancy management using Liposorber D, an LA technique that operates on whole blood. Before pregnancy, the patient was on lipid-lowering therapy with Lomitapide and Evolocumab, which were discontinued upon conception. A multidisciplinary team opted for weekly Liposorber D sessions throughout the pregnancy.

The treatment significantly reduced total cholesterol and LDL cholesterol levels without notable side effects. The pregnancy progressed normally, and at 37 weeks of gestation, the patient delivered a healthy male infant via cesarean section for reasons unrelated to LA.

This marks the first reported case of a successful pregnancy managed with Liposorber D.

Reference
Stefanutti C, Perrone G, Galoppi P, et al. Management of a young HoFH patient during pregnancy using Lipoprotein Apheresis (whole blood): A novel experience. Transfus Apher Sci. 2024;64(1):104062. doi: 10.1016/j.transci.2024.104062. Epub ahead of print. PMID: 39721136.