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Growth Hormone Deficiency
Journal Scan

Thyroid function may help in diagnosing children with isolated IGHD and IPH

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Children with isolated growth hormone deficiency (IGHD) with isolated pituitary hypoplasia (IPH) had lower levels of FT4 than in children with IGHD without pituitary abnormalities, according to a study.

In this retrospective observational study, 100 children with short stature and IPH were enrolled, including 68 children with IGHD. An additional 68 children without pituitary abnormalities were age-matched and included as the control group.

Lower height standard deviation score (HSDS) was significantly lower in children in the IPH group compared to children in the control group. HSDS-target height standard deviation score (THSDS), free thyroxine (FT4), insulin-like growth factor-1 standard deviation score (IGF-1SDS), and pituitary height was also significantly lower in these children. The value of the area under the curve was 0.701 when the cut-off value for FT4 was ≤ 16.43 pmol/L and the sensitivity was 72.1 and the specificity was 61.8%.

In all children with short stature and IPH, FT4 levels were positively correlated with FT3, GH peak, and IGF-1 SDS levels.

Reference
Hu Y, Zhu L, Liu Q, et al. Thyroid function in children with short stature accompanied by isolated pituitary hypoplasia. Hormones (Athens). 2021;doi: 10.1007/s42000-021-00323-0. Epub ahead of print. PMID: 34582001.

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