Thyroid function may help in diagnosing children with isolated IGHD and IPH
Children with isolated growth hormone deficiency (IGHD) with isolated pituitary hypoplasia (IPH) had lower levels of FT4 than in children with IGHD without pituitary abnormalities, according to a study.
In this retrospective observational study, 100 children with short stature and IPH were enrolled, including 68 children with IGHD. An additional 68 children without pituitary abnormalities were age-matched and included as the control group.
Lower height standard deviation score (HSDS) was significantly lower in children in the IPH group compared to children in the control group. HSDS-target height standard deviation score (THSDS), free thyroxine (FT4), insulin-like growth factor-1 standard deviation score (IGF-1SDS), and pituitary height was also significantly lower in these children. The value of the area under the curve was 0.701 when the cut-off value for FT4 was ≤ 16.43 pmol/L and the sensitivity was 72.1 and the specificity was 61.8%.
In all children with short stature and IPH, FT4 levels were positively correlated with FT3, GH peak, and IGF-1 SDS levels.
Hu Y, Zhu L, Liu Q, et al. Thyroid function in children with short stature accompanied by isolated pituitary hypoplasia. Hormones (Athens). 2021;doi: 10.1007/s42000-021-00323-0. Epub ahead of print. PMID: 34582001.