IGF-1 levels significantly lower in children with Prader–Willi syndrome
Very young children with Prader–Willi syndrome (PWS) have lower insulin growth factor-1 (IGF-1) than their healthy peers, independent of anthropometric parameters and nutritional status, according to a study.
In this small retrospective analysis, IGF-1 was compared between children with PWS (median age; 14 months) and healthy peers matched for age, sex, anthropometric parameters.
IGF-1 SDS was found to be significantly lower in patients with PWS than in the control group (−1.56 vs −1.01, P = 0.003) after adjusting for confounding variables. There was no difference in IGF-1 between patients with PWS with growth hormone sufficiency and patients with growth hormone deficiency.
Koizumi M, Konishi A, Etani Y, et al. Circulating insulin-like growth factor 1 levels are reduced in very young children with Prader–Willi syndrome independent of anthropometric parameters and nutritional status. Clin Endocrinol. 2021; https://doi.org/10.1111/cen.14635.