Heights similar between patients with isolated GH deficiency, idiopathic short stature

The final heights of patients with isolated GH deficiency (IGHD) and treated idiopathic short stature (ISS) are similar, with treated groups being taller than untreated groups, according to a study.

This retrospective descriptive study compared 67 treated children with IGHD to 30 children with treated ISS and 42 children with untreated ISS.

IGHD children had a height gain of 1.24 SD with a final height of -1.52 SD, ISS-treated had a gain of 1.47 SD and final height of -1.31 SD, and ISS-untreated had a gain of 0.37 SD and a final height of -2.03 SD.

Target heights were not reached in IGHD and ISS-untreated children; ISS-treated patients surpassed their target height by 0.29 SD.

Reference
Ariza-Jimenez AB, Leiva Gea I, Martinez-Aedo Ollero MJ, et al. Isolated Growth Hormone Deficiency and Idiopathic Short Stature: Comparative Efficiency after Growth Hormone Treatment up to Adult Height. J Clin Med. 2021;10(21):4988. doi: 10.3390/jcm10214988. PMID: 34768508