Growth Hormone Disorders
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Growth hormone replacement safe in children with small sellar cysts

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Most small pituitary cysts found on pediatric brain MRIs do not require surgery and do not appear to be significantly enlarged due to growth hormone replacement (GHR), according to a study.

Small pituitary cysts are often found in patients with growth hormone deficiency (GHD).

In this retrospective review, 101 children ≤19 years of age were found to have brain cysts after undergoing MRIs, of which 25 had confirmed GHD. Those with GHD had a higher mean age compared to those who did not (11.2 vs 8.4 years).

Compared to patients without GHD, mean cyst volume in patients with GHD was not significantly smaller.

A total of 21 patients with GHD who received GHR had follow-up MRIs. Pituitary cyst size did not change in 10 patients, shrunk in 2 patients, disappeared in 7 patients, and enlarged in 2 patients. No patients on GHR needed surgical intervention.

Sheldon BL, O’Brien MW, Adamo MA. Growth hormone replacement therapy: is it safe to use in children with asymptomatic pituitary lesions? J Pediatr Endocrinol Metab. 2021;doi: 10.1515/jpem-2021-0479. Epub ahead of print. PMID: 34407327.