Survey highlights growing preference for non-contrast MRI in isolated GHD diagnosis
High-resolution non-contrast MRI shows strong diagnostic efficacy for evaluating isolated growth hormone deficiency (GHD), which could lead to a shift away from using gadolinium-based contrast agents (GBCAs) in clinical practice, according to survey results.
The survey conducted among members of the Pediatric Endocrine Society (PES) explored brain MRI practices for isolated GHD, comparing the use of GBCAs with non-contrast MRI techniques. The 15-question survey, distributed to 1,553 PES members, gathered data on GBCA use, access to non-contrast imaging, and awareness of gadolinium retention risks.
The results found that 85% of respondents regularly order brain MRIs for isolated GHD, with 60% opting for GBCAs. However, although most have access to high-resolution non-contrast imaging, 54% were unaware of the risks associated with gadolinium retention. The findings suggest that non-contrast MRI is effective diagnostically, prompting consideration of reduced reliance on GBCAs. These results could inform future updates to PES guidelines on the evaluation of isolated GHD.
Reference
Mak D, Breidbart E, Mehta S, et al. Surveying Current Practices in the Use of Gadolinium-Based Contrast Agents for Routine Brain Magnetic Resonance Imaging in the Evaluation of Isolated Growth Hormone Deficiency Among U.S. Pediatric Endocrinologists. Horm Res Paediatr. 2024;1-10. doi: 10.1159/000541661. Epub ahead of print. PMID: 39348816.
