Harlequin color change linked to congenital insensitivity to pain with anhidrosis

Harlequin color change, a distinct skin phenomenon characterized by unilateral flushing, may be an early indicator of congenital insensitivity to pain with anhidrosis (CIPA), according to a study.

In this study, researchers surveyed families and individuals closely associated with patients with CIPA. According to the findings, harlequin color change, marked by unilateral flushing of the face or body, was consistently reported by respondents. This phenomenon typically appears alongside the initial symptoms of CIPA, often coinciding with the diagnosis.

These results underscore the importance of clinicians recognizing harlequin color change as a potential indicator of CIPA, particularly during the early stages of the disease, when diagnosis can be challenging.

Reference
Maazi M, Lam JM. Congenital Insensitivity to Pain With Anhidrosis Is Associated With Harlequin Color Change: A Survey Study. Pediatr Dermatol. 2024;doi: 10.1111/pde.15784. Epub ahead of print. PMID: 39420746.