Study links hyperuricemia, gout, and vitamin D deficiency
Hyperuricemia and gout significantly increase the risk of Vitamin D deficiency, with evidence suggesting a causal relationship between gout-related genetic factors and lower Vitamin D levels, according to a study.
Researchers analyzed data from 13,532 patients and over 22,800 participants from a health and nutrition survey. A two-sample Mendelian randomization analysis further investigated the causal link between gout and 25-hydroxyvitamin D (25(OH)D).
There was a positive correlation between higher uric acid levels, gout, and the risk of Vitamin D deficiency. The study identified a dose-response relationship, with uric acid thresholds of 307.5 and 316.1 µmol/L associated with increased deficiency risk. Mediation analysis found that serum uric acid and body mass index accounted for 29.4% and 37.1% of the effect of gout on Vitamin D deficiency, respectively.
Mendelian randomization analysis confirmed a causal association between gout-related genetic variants and lower 25(OH)D levels, further validated through sensitivity and genetic risk score analyses.
Reference
Han Y, Han X, Zhao H, et al. The exploration of the relationship between hyperuricemia, gout and Vitamin D deficiency. J Nutr Biochem. 2025;109848. doi: 10.1016/j.jnutbio.2025.109848. Epub ahead of print. PMID: 39863084.