Frail patients with acute decompensated heart failure may benefit from early physical rehab
Frail patients with acute decompensated heart failure (ADHF) may benefit more from early physical rehabilitation intervention than patients with better frailty status at baseline, according to a study.
In this secondary analysis of data from the Rehabilitation Therapy in Older Acute Heart Failure Patients (REHAB-HF) trial including 337 patients ≥ 60 years hospitalized for ADHF, were analyzed to assess whether baseline frailty impacted the benefit of physical rehabilitation. The mean (SD) age of participants was 72 (8) years.
At baseline, 57% (n = 192) of patients were frail and 43% (n = 145) were prefrail.
There was a 2.6-fold larger improvement in Short Physical Performance Battery (SPPB) score in frail patients in the treatment arm for the primary trial endpoint versus prefrail patients.
“Trends consistently favored a larger intervention effect size, with significant improvement among frail vs prefrail participants for 6-minute walk distance, [quality of life], and the geriatric depression score, but interactions did not achieve significance,” the authors wrote.
Pandey A, Kitzman DW, Nelson MB, et al. Frailty and Effects of a Multidomain Physical Rehabilitation Intervention Among Older Patients Hospitalized for Acute Heart Failure: A Secondary Analysis of a Randomized Clinical Trial. JAMA Cardiol. Published online January 04, 2023. doi:10.1001/jamacardio.2022.4903